/ en Mon, 03 Mar 25 13:06:44 -0500 /news-events/nih-research-matters/cancer-cells-can-cooperate-grow <span class="field field--name-title field--type-string field--label-hidden">Cancer cells can cooperate to grow</span> <span class="field field--name-uid field--type-entity-reference field--label-hidden"><span>hillerjm</span></span> <span class="field field--name-created field--type-created field--label-hidden"><time datetime="2025-03-03T13:06:44-05:00" title="Monday, March 3, 2025 - 13:06" class="datetime">Mon, 03/03/2025 - 13:06</time> </span> <div class="field field--name-field-featured-media field--type-entity-reference field--label-hidden field__item"><article class="media media--type-image media--view-mode-float-right"> <div class="field field--name-field-media-image field--type-image field--label-visually_hidden"> <div class="field__label visually-hidden">Image</div> <div class="field__item"> <img loading="eager" srcset="/sites/default/files/styles/max_325x325/public/2025-03/20250304-cancer.jpg?itok=EgJFTaOB 325w, /sites/default/files/styles/max_650x650/public/2025-03/20250304-cancer.jpg?itok=LTY3zYgx 650w, /sites/default/files/styles/max_1300x1300/public/2025-03/20250304-cancer.jpg?itok=Ik7UfNPU 700w" sizes="(min-width: 1024px) 325px, (min-width: 640px) 50vw, 100vw" width="650" height="auto" src="/sites/default/files/styles/max_650x650/public/2025-03/20250304-cancer.jpg?itok=LTY3zYgx" alt="Human breast cancer cells." title="20250304-cancer.jpg"/> </div> </div> <div class="clearfix text-formatted field field--name-field-long-caption field--type-text-long field--label-hidden field__item">Every tumor cell type tested by the researchers — including this group of human breast cancer cells — required cooperation to survive under amino acid scarcity. Cell nuclei are labelled blue. Cell membranes are labelled with green and magenta.</div> <div class="field field--name-field-credit field--type-string field--label-hidden field__item">Carmofon lab / NYU</div> </article> </div> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p>Cancer cells, which can grow and divide rapidly, often compete with each other and with surrounding normal cells for nutrients, oxygen, and other substances. However, studies have suggested that cells in tumors may sometimes need to cooperate to survive. A better understanding of how cancer cells cooperate could provide new targets for treatments. But this aspect of tumor growth has not been studied in depth.</p> <p>In a new study, funded in part by NIH, a team led by Dr. Carlos Carmona-Fontaine from New York University investigated a peculiar characteristic of cell growth called the Allee effect. In the Allee effect, the viability of a cell population drops below a certain cell density. This suggests the cells are somehow cooperating to survive. The study appeared on February 19, 2025, in <em>Nature</em>.</p> <p>To look at whether cancer cells exhibit an Allee effect, the researchers grew several types of cancer cells with various restricted nutrients. They found that depriving the cells of an amino acid that the cells need to grow appeared to create an Allee effect. Only higher-density cell populations survived under these conditions. This indicated that a cooperative survival strategy had kicked in.</p> <p>The team then further explored how cancer cells might be cooperating to survive in low-amino acid environments. Chains of amino acids called oligopeptides can be broken down by cells into individual amino acids. The scientists found that cancer cells released substances into their immediate environment that broke nearby oligopeptides down. Because this occurred outside the cancer cells, any cell in the immediate vicinity could use the resulting free amino acids.</p> <p>Further experiments found that a single enzyme called CNDP2 was needed to extract the amino acids from oligopeptides. When the researchers blocked CNDP2 activity in a variety of cancer cell types, the cells could no longer break down oligopeptides, and the populations died.</p> <p>The team next tested whether blocking CNDP2 could slow or stop tumor growth in living animals. They implanted mice with a type of lung cancer cell known to be sensitive to amino acid deprivation and fed the mice a diet designed to reduce circulating levels of these nutrients. Mice injected with a drug called bestatin, which blocks CNDP2, had substantially smaller tumors than mice injected with an inactive control compound.</p> <p>Even more dramatic results were seen when the team used techniques to delete the gene that produces CNDP2 from cancer cells. When fed the special diet, a significant number of the mice injected with these cells didn’t develop observable tumors. These results suggest that inhibiting CNDP2 may be a promising therapeutic approach for cancer types sensitive to amino acid deprivation.</p> <p>“Competition is still critical for tumor evolution and cancer progression, but our study suggests that cooperative interactions within tumors are also important,” Carmona-Fontaine says. “Thinking about [these] mechanisms that tumor cells exploit can inform future therapies.”</p> <p>—by Sharon Reynolds</p></div> <div class="field field--name-field-related-articles field--type-link field--label-hidden field__items"> <div class="field__item"><a href="/news-events/nih-research-matters/research-context-detecting-cancer">Research in Context: Detecting Cancer</a></div> <div class="field__item"><a href="/news-events/nih-research-matters/mapping-how-cancers-form-spread">Mapping How Cancers Form and Spread</a></div> <div class="field__item"><a href="/news-events/nih-research-matters/keto-diet-enhances-experimental-cancer-therapy-mice">Keto Diet Enhances Experimental Cancer Therapy in Mice</a></div> <div class="field__item"><a href="/news-events/nih-research-matters/advancing-molecular-insights-into-cancer">Advancing Molecular Insights into Cancer</a></div> <div class="field__item"><a href="/news-events/nih-research-matters/cancer-cells-drain-energy-immune-cells">Cancer Cells Drain Energy from Immune Cells</a></div> <div class="field__item"><a href="/news-events/nih-research-matters/neighbors-help-cancer-cells-resist-treatment">Neighbors Help Cancer Cells Resist Treatment</a></div> <div class="field__item"><a href="https://www.cancer.gov/about-cancer/understanding/what-is-cancer">What Is Cancer?</a></div> <div class="field__item"><a href="https://www.cancer.gov/about-nci/organization/dcb/research-portfolio/tbmr">Tumor Biology and Microenvironment</a></div> </div> <div class="clearfix text-formatted field field--name-field-at-a-glance field--type-text-long field--label-hidden field__item"><h3>At a Glance</h3> <ul> <li>Scientists found that, when deprived of amino acids, cancer cells cooperated to extract and share them from their environment.</li> <li>Blocking a protein called CNDP2 shut down this cooperative survival strategy, suggesting a new potential target for cancer treatment.</li> </ul></div> <div class="clearfix text-formatted field field--name-field-reference field--type-text-long field--label-above"> <div class="field__label">References</div> <div class="field__item"><a href="https://pubmed.ncbi.nlm.nih.gov/39972131/">Cooperative nutrient scavenging is an evolutionary advantage in cancer.</a> Guzelsoy G, Elorza SD, Ros M, Schachtner LT, Hayashi M, Hobson-Gutierrez S, Rundstrom P, Brunner JS, Pillai R, Walkowicz WE, Finley LWS, Deforet M, Papagiannakopoulos T, Carmona-Fontaine C. <em>Nature</em>. 2025 Feb 19. doi: 10.1038/s41586-025-08588-w. Online ahead of print. PMID: 39972131.</div> </div> <div class="field field--name-field-edition-date field--type-datetime field--label-hidden field__item"><time datetime="2025-03-04T12:00:00Z" class="datetime">Tue, 03/04/2025 - 12:00</time> </div> <div class="field field--name-field-add-subtitle field--type-boolean field--label-above"> <div class="field__label">Add subtitle</div> <div class="field__item">Off</div> </div> Mon, 03 Mar 2025 18:06:44 +0000 hillerjm 15541 at /news-events/nih-research-matters/diabetes-boosts-antibiotic-resistance-mice <span class="field field--name-title field--type-string field--label-hidden">Diabetes boosts antibiotic resistance in mice</span> <span class="field field--name-uid field--type-entity-reference field--label-hidden"><span>hillerjm</span></span> <span class="field field--name-created field--type-created field--label-hidden"><time datetime="2025-03-03T13:05:53-05:00" title="Monday, March 3, 2025 - 13:05" class="datetime">Mon, 03/03/2025 - 13:05</time> </span> <div class="field field--name-field-featured-media field--type-entity-reference field--label-hidden field__item"><article class="media media--type-image media--view-mode-float-right"> <div class="field field--name-field-media-image field--type-image field--label-visually_hidden"> <div class="field__label visually-hidden">Image</div> <div class="field__item"> <img loading="eager" srcset="/sites/default/files/styles/max_325x325/public/2025-03/20250304-mrsa.jpg?itok=LcHtQV1h 325w, /sites/default/files/styles/max_650x650/public/2025-03/20250304-mrsa.jpg?itok=UXBY2iyq 650w, /sites/default/files/styles/max_1300x1300/public/2025-03/20250304-mrsa.jpg?itok=jopYRhjC 700w" sizes="(min-width: 1024px) 325px, (min-width: 640px) 50vw, 100vw" width="650" height="auto" src="/sites/default/files/styles/max_650x650/public/2025-03/20250304-mrsa.jpg?itok=UXBY2iyq" alt="Methicillin-resistant Staphylococcus aureus, or MRSA, bacteria." title="20250304-mrsa.jpg"/> </div> </div> <div class="clearfix text-formatted field field--name-field-long-caption field--type-text-long field--label-hidden field__item">Colorized scanning electron micrograph of methicillin-resistant Staphylococcus aureus (MRSA) bacteria.</div> <div class="field field--name-field-credit field--type-string field--label-hidden field__item">NIAID</div> </article> </div> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p>People with diabetes tend to get more infections than those without. This is in part because people with diabetes have too much sugar, or glucose, in their blood, which promotes bacterial growth. Diabetes also suppresses the immune system, which makes it hard to fight infections. These factors can raise the risk of developing bacterial infections of the skin and soft tissues, including tendons and ligaments. Severe infections may require amputation of toes, feet, or other extremities.</p> <p>Diabetic skin and tissue infections are often treated with antibiotics, but drug-resistant bacteria are a growing concern. <em>Staphylococcus aureus, </em>or staph, is the most common cause of such infections in people with diabetes. But the underlying links between diabetes, bacterial infection, and antibiotic resistance have been unclear.</p> <p>A research team led by Drs. Brian Conlon and Lance Thurlow of the University of North Carolina set out to learn more. The scientists began by giving diabetic and non-diabetic mice skin infections with <em>S. aureus. </em>The mice then received four daily treatments with the antibiotic rifampicin. <em>S. aureus </em>is prone to develop rapid resistance to this drug. The results appeared in <em>Science Advances</em> on February 12, 2025.</p> <p>A day after antibiotic treatment had ended, the researchers found that <em>S. aureus</em> levels were significantly higher in diabetic than in non-diabetic mice. This was expected, since diabetes can fuel the growth of bacteria. But the scientists also found that the diabetic mice quickly evolved resistance to the antibiotic over just a four-day period. In contrast, no signs of antibiotic resistance were observed in the non-diabetic mice. Additional studies showed that when drug-resistant strains of <em>S. aureus </em>emerge, their numbers rapidly expand during antibiotic treatment.</p> <p>The researchers assessed different factors that could lead to this increased drug resistance. They found that faulty immune cells contribute to the emergence of drug resistance in mice with diabetes. However, high glucose levels, or hyperglycemia, has a much larger impact. </p> <p>In a final experiment, the scientists assessed the effects of improved glucose control. They gave daily doses of insulin to diabetic mice. These insulin treatments only partially normalized blood glucose levels. Yet they significantly reduced the emergence of drug-resistant bacteria. Taken together, the results suggest that even partial control of blood glucose may help to combat antibiotic resistance.</p> <p>“Resistance and its spread are not only associated with the prescription of drugs, but also the health status of those that are taking antibiotics,” Conlon says. “Controlling blood glucose then becomes really important. When we gave our mice insulin, we were able to bring their blood sugar back to normal and we didn't get this rapid proliferation of resistant bacteria.”</p> <p>The findings suggest that improved glucose control could help prevent the emergence of drug-resistant bacteria in people with diabetes.</p> <p>—by Vicki Contie</p></div> <div class="field field--name-field-related-articles field--type-link field--label-hidden field__items"> <div class="field__item"><a href="/">Designing a New Antibiotic to Combat Drug Resistance</a></div> <div class="field__item"><a href="/">Immune Boost May Protect Against Multiple Hospital-Acquired Infections</a></div> <div class="field__item"><a href="/">Probiotic Blocks Staph Bacteria from Colonizing People</a></div> <div class="field__item"><a href="/">Using Viruses To Treat Antibiotic-Resistant Bacterial Infections</a></div> <div class="field__item"><a href="https://newsinhealth.nih.gov/2023/10/stamping-out-superbugs">Stamping Out Superbugs: A Clear and Present Danger</a></div> <div class="field__item"><a href="https://www.niaid.nih.gov/research/antimicrobial-resistance">Antimicrobial (Drug) Resistance</a></div> <div class="field__item"><a href="https://www.niddk.nih.gov/health-information/diabetes">Diabetes</a></div> <div class="field__item"><a href="https://www.cdc.gov/diabetes/signs-symptoms/diabetes-and-your-skin.html">Diabetes and Your Skin (CDC)</a></div> </div> <div class="clearfix text-formatted field field--name-field-at-a-glance field--type-text-long field--label-hidden field__item"><h3>At a Glance</h3> <ul> <li>Researchers found that infectious bacteria in diabetic mice rapidly evolved resistance to antibiotics.</li> <li>Controlling blood sugar in the mice via insulin significantly reduced the emergence of drug-resistant bacteria.</li> </ul></div> <div class="clearfix text-formatted field field--name-field-reference field--type-text-long field--label-above"> <div class="field__label">References</div> <div class="field__item"><a href="https://pubmed.ncbi.nlm.nih.gov/39937900/">Diabetes potentiates the emergence and expansion of antibiotic resistance.</a> Shook JC, Genito CJ, Darwitz BP, Tyson KJ, Velez AZ, Bridwell SK, Parsons JB, Rowe SE, Marshall CW, Conlon BP, Thurlow LR. <em>Sci Adv.</em> 2025 Feb 14;11(7):eads1591. doi: 10.1126/sciadv.ads1591. Epub 2025 Feb 12. PMID: 39937900.</div> </div> <div class="field field--name-field-edition-date field--type-datetime field--label-hidden field__item"><time datetime="2025-03-04T12:00:00Z" class="datetime">Tue, 03/04/2025 - 12:00</time> </div> <div class="field field--name-field-add-subtitle field--type-boolean field--label-above"> <div class="field__label">Add subtitle</div> <div class="field__item">Off</div> </div> Mon, 03 Mar 2025 18:05:53 +0000 hillerjm 17551 at /news-events/nih-research-matters/tracking-diet-stool-samples <span class="field field--name-title field--type-string field--label-hidden">Tracking diet from stool samples</span> <span class="field field--name-uid field--type-entity-reference field--label-hidden"><span>hillerjm</span></span> <span class="field field--name-created field--type-created field--label-hidden"><time datetime="2025-03-03T13:05:12-05:00" title="Monday, March 3, 2025 - 13:05" class="datetime">Mon, 03/03/2025 - 13:05</time> </span> <div class="field field--name-field-featured-media field--type-entity-reference field--label-hidden field__item"><article class="media media--type-image media--view-mode-float-right"> <div class="field field--name-field-media-image field--type-image field--label-visually_hidden"> <div class="field__label visually-hidden">Image</div> <div class="field__item"> <img loading="eager" srcset="/sites/default/files/styles/max_325x325/public/2025-03/20250304-food.jpg?itok=Z_CnGJUo 325w, /sites/default/files/styles/max_650x650/public/2025-03/20250304-food.jpg?itok=g2ucNzPU 650w, /sites/default/files/styles/max_1300x1300/public/2025-03/20250304-food.jpg?itok=jVKY5nmx 1200w" sizes="(min-width: 1024px) 325px, (min-width: 640px) 50vw, 100vw" width="650" height="auto" src="/sites/default/files/styles/max_650x650/public/2025-03/20250304-food.jpg?itok=g2ucNzPU" alt="A table displaying a variety of foods with a crowd of people standing around and talking behind it." title="20250304-food.jpg"/> </div> </div> <div class="clearfix text-formatted field field--name-field-long-caption field--type-text-long field--label-hidden field__item">Accurately tracking the foods people eat has been a serious challenge in nutrition research.</div> <div class="field field--name-field-credit field--type-string field--label-hidden field__item">Rawpixel.com / Adobe Stock</div> </article> </div> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p>Diet influences many aspects of human health. Yet tracking dietary intake remains challenging. Typical approaches include questionnaires and food diaries. Questionnaires are limited by participants’ ability to accurately remember their food intake. Food diaries provide more detailed information but require more effort from participants.</p> <p>To overcome these limitations, a team of researchers, led by Drs. Christian Diener and Sean Gibbons at the Institute for Systems Biology, developed a method to detect and measure food-derived DNA in human stool samples. This can be used to estimate a person’s dietary intake. Nutrient intake can then be estimated based on the nutrient content of the foods found. A description of the method, called Metagenomic Estimation of Dietary Intake (MEDI), and its use appeared in <em>Nature Metabolism </em>on February 18, 2025.</p> <p>The team began by constructing a database of full or partial genomes for more than 400 organisms that people eat. These were linked to nutritional profiles for different food items and preparation types. Next, the team developed an algorithm to match DNA from stool samples to its source food in the database. Only a tiny fraction of the DNA in stool comes from food. Most comes from the person or their gut microbes. But the team demonstrated that MEDI could accurately detect and measure diet-derived DNA sequences, even when they made up as little as 0.001% of the total DNA.</p> <p>To test whether MEDI results accurately reflected food intake patterns, the researchers analyzed genome sequences in stool samples from two controlled feeding studies. Participants in the studies were separated into two groups, with each being fed a controlled diet. In both studies, MEDI accurately reflected the differences in dietary intake between the groups. For one of the studies, participants also kept detailed daily food diaries, allowing estimates of detailed nutrient intake. MEDI estimates agreed with the food diary estimates for calorie, protein, carbohydrate, potassium, cholesterol, and vitamin B<sub>12</sub> intake.</p> <p>In a dataset of infant stool samples, MEDI identified a steady increase in the prevalence of food-derived DNA beginning around 160 days of age, corresponding to the start of solid food intake. In adult samples, MEDI estimates of diet composition agreed with those obtained from food frequency questionnaires.</p> <p>The team also used MEDI to identify dietary patterns associated with metabolic syndrome in study participants without dietary records. Metabolic syndrome is a group of conditions, including high blood pressure and high blood sugar, that increase the risk of coronary heart disease, diabetes, and stroke. Consistent with earlier findings, the team found that people with metabolic syndrome had higher intake of animal-based foods and lower intake of plant-based foods than those without metabolic syndrome. Metabolic syndrome was also associated with higher intake of specific nutrients, including lactose, cholesterol, and certain fatty acids.</p> <p>“For decades, nutrition research has depended on self-reported diaries and questionnaires—approaches that require a high degree of effort and compliance from research participants,” Diener says. “How many strawberries did I eat two days ago? Did I have one glass of orange juice with breakfast, or two?”</p> <p>With further development, food-derived DNA from stool samples could greatly improve how diets are tracked to improve the accuracy of nutrition studies. But MEDI can’t detect items that lack DNA, such as coffee and many other beverages, so it may still need to be supplemented with other approaches.</p> <p>—by Brian Doctrow, Ph.D.</p></div> <div class="field field--name-field-related-articles field--type-link field--label-hidden field__items"> <div class="field__item"><a href="/">Calorie Restriction and Human Muscle Function</a></div> <div class="field__item"><a href="/">Research in Context: Obesity and Metabolic Health</a></div> <div class="field__item"><a href="/">Health Benefits of Dietary Fibers Vary</a></div> <div class="field__item"><a href="/">Fiber In Diet Linked to Cancer Immunotherapy Response</a></div> <div class="field__item"><a href="/">Low-Fat Diet Compared to Low-Carb Diet</a></div> <div class="field__item"><a href="/">Diets Improve but Remain Poor For Most U.S. Children</a></div> <div class="field__item"><a href="/">Eating Highly Processed Foods Linked To Weight Gain</a></div> <div class="field__item"><a href="/">How Dietary Factors Influence Disease Risk</a></div> <div class="field__item"><a href="https://newsinhealth.nih.gov/2019/07/plan-your-plate">Plan Your Plate: Shifting to a Healthy Eating Style</a></div> <div class="field__item"><a href="https://www.nhlbi.nih.gov/health/metabolic-syndrome">What Is Metabolic Syndrome?</a></div> </div> <div class="clearfix text-formatted field field--name-field-at-a-glance field--type-text-long field--label-hidden field__item"><h3>At a Glance</h3> <ul> <li>Researchers developed a way to track what people ate by analyzing DNA from stool samples.</li> <li>Such a method could improve the accuracy of studies that track food intake.</li> </ul></div> <div class="clearfix text-formatted field field--name-field-reference field--type-text-long field--label-above"> <div class="field__label">References</div> <div class="field__item"><a href="https://pubmed.ncbi.nlm.nih.gov/39966520/">Metagenomic estimation of dietary intake from human stool.</a> Diener C, Holscher HD, Filek K, Corbin KD, Moissl-Eichinger C, Gibbons SM. <em>Nat Metab.</em> 2025 Feb 18. doi: 10.1038/s42255-025-01220-1. Online ahead of print. PMID: 39966520.</div> </div> <div class="field field--name-field-edition-date field--type-datetime field--label-hidden field__item"><time datetime="2025-03-04T12:00:00Z" class="datetime">Tue, 03/04/2025 - 12:00</time> </div> <div class="field field--name-field-add-subtitle field--type-boolean field--label-above"> <div class="field__label">Add subtitle</div> <div class="field__item">Off</div> </div> Mon, 03 Mar 2025 18:05:12 +0000 hillerjm 17556 at /node/14906 <span class="field field--name-title field--type-string field--label-hidden">In a Q&A with Washington Post Health 202, Dr. Collins discusses the All of Us Research Program</span> <span class="field field--name-uid field--type-entity-reference field--label-hidden"><span>Anonymous</span></span> <span class="field field--name-created field--type-created field--label-hidden"><time datetime="2025-03-03T10:42:18-05:00" title="Monday, March 3, 2025 - 10:42" class="datetime">Mon, 03/03/2025 - 10:42</time> </span> <div class="field field--name-field-link-description field--type-string-long field--label-hidden field__item">Dr. Collins sits down with Washington Post’s Paige Winfield Cunningham to discuss enrolling 1 million diverse participants in the All of Us Research Program. Other topics covered in the conversation include the opioid crisis, and the NIH budget. Washington Post. January 16, 2018.</div> <div class="field field--name-field-item-link field--type-link field--label-hidden field__item"><a href="https://www.washingtonpost.com/news/powerpost/paloma/the-health-202/2018/01/16/the-health-202-nih-wants-1-million-americans-to-contribute-to-new-pool-of-gene-data/5a5ba45a30fb0469e8840135/?utm_term=.2dbdbb68a796">In a Q&A with Washington Post Health 202, Dr. Collins discusses the All of Us R…</a></div> <div class="field field--name-field-site-section field--type-entity-reference field--label-hidden field__item"><a href="/taxonomy/term/536" hreflang="en">The NIH Director</a></div> <div class="field field--name-field-organization field--type-entity-reference field--label-hidden field__item"><a href="/taxonomy/term/6" hreflang="en">OD</a></div> <div class="field field--name-field-publish-date field--type-datetime field--label-hidden field__item"><time datetime="2018-01-16T12:00:00Z" class="datetime">Tue, 01/16/2018 - 12:00</time> </div> Mon, 03 Mar 2025 15:42:18 +0000 Anonymous 14906 at /node/14901 <span class="field field--name-title field--type-string field--label-hidden">Dr. Collins joins WNYC's The Takeaway to talk about All of Us and changing the one-size-fits-all approach to health care</span> <span class="field field--name-uid field--type-entity-reference field--label-hidden"><span>Anonymous</span></span> <span class="field field--name-created field--type-created field--label-hidden"><time datetime="2025-03-03T10:42:18-05:00" title="Monday, March 3, 2025 - 10:42" class="datetime">Mon, 03/03/2025 - 10:42</time> </span> <div class="field field--name-field-link-description field--type-string-long field--label-hidden field__item">Dr. Collins talks to The Takeaway's Todd Zwillich about building a diverse cohort of 1 million Americans to understand how environmental exposures, diet, exercise, and genetics affect our personal health.</div> <div class="field field--name-field-item-link field--type-link field--label-hidden field__item"><a href="https://www.wnyc.org/story/creating-worlds-largest-genetic-library">Dr. Collins joins WNYC's The Takeaway to talk about All of Us and changing the …</a></div> <div class="field field--name-field-site-section field--type-entity-reference field--label-hidden field__item"><a href="/taxonomy/term/536" hreflang="en">The NIH Director</a></div> <div class="field field--name-field-organization field--type-entity-reference field--label-hidden field__item"><a href="/taxonomy/term/6" hreflang="en">OD</a></div> <div class="field field--name-field-publish-date field--type-datetime field--label-hidden field__item"><time datetime="2018-01-18T12:00:00Z" class="datetime">Thu, 01/18/2018 - 12:00</time> </div> Mon, 03 Mar 2025 15:42:18 +0000 Anonymous 14901 at /node/14896 <span class="field field--name-title field--type-string field--label-hidden">Dr. Collins speaks to BBC News about the therapeutic potential of music </span> <span class="field field--name-uid field--type-entity-reference field--label-hidden"><span>Anonymous</span></span> <span class="field field--name-created field--type-created field--label-hidden"><time datetime="2025-03-03T10:42:18-05:00" title="Monday, March 3, 2025 - 10:42" class="datetime">Mon, 03/03/2025 - 10:42</time> </span> <div class="field field--name-field-link-description field--type-string-long field--label-hidden field__item">Dr. Collins discusses NIH’s partnership with the Kennedy Center called Sound Health to research scientific links between music and health.</div> <div class="field field--name-field-item-link field--type-link field--label-hidden field__item"><a href="http://www.bbc.com/news/av/world-us-canada-42951478/the-extraordinary-healing-powers-of-music">Dr. Collins speaks to BBC News about the therapeutic potential of music </a></div> <div class="field field--name-field-site-section field--type-entity-reference field--label-hidden field__item"><a href="/taxonomy/term/536" hreflang="en">The NIH Director</a></div> <div class="field field--name-field-organization field--type-entity-reference field--label-hidden field__item"><a href="/taxonomy/term/6" hreflang="en">OD</a></div> <div class="field field--name-field-publish-date field--type-datetime field--label-hidden field__item"><time datetime="2018-02-05T12:00:00Z" class="datetime">Mon, 02/05/2018 - 12:00</time> </div> Mon, 03 Mar 2025 15:42:18 +0000 Anonymous 14896 at /node/14891 <span class="field field--name-title field--type-string field--label-hidden">In an interview with Ethix, Dr. Collins covers a range of topics, from the opioid crisis to DNA privacy issues </span> <span class="field field--name-uid field--type-entity-reference field--label-hidden"><span>Anonymous</span></span> <span class="field field--name-created field--type-created field--label-hidden"><time datetime="2025-03-03T10:42:18-05:00" title="Monday, March 3, 2025 - 10:42" class="datetime">Mon, 03/03/2025 - 10:42</time> </span> <div class="field field--name-field-link-description field--type-string-long field--label-hidden field__item">Dr. Collins answers questions from Mark Neuenschwander and Al Erisman on a number of topics including peer review, the opioid crisis, joining the NIH and leading the Human Genome Project, wellness research, and privacy issues related to precision medicine. Ethix. February 28, 2018.</div> <div class="field field--name-field-item-link field--type-link field--label-hidden field__item"><a href="https://ethix.org/2018/02/28/francis-s-collins-md-phd">In an interview with Ethix, Dr. Collins covers a range of topics, from the opio…</a></div> <div class="field field--name-field-site-section field--type-entity-reference field--label-hidden field__item"><a href="/taxonomy/term/536" hreflang="en">The NIH Director</a></div> <div class="field field--name-field-organization field--type-entity-reference field--label-hidden field__item"><a href="/taxonomy/term/6" hreflang="en">OD</a></div> <div class="field field--name-field-publish-date field--type-datetime field--label-hidden field__item"><time datetime="2018-02-28T12:00:00Z" class="datetime">Wed, 02/28/2018 - 12:00</time> </div> Mon, 03 Mar 2025 15:42:18 +0000 Anonymous 14891 at /node/14886 <span class="field field--name-title field--type-string field--label-hidden">In a Q&A with WebMD, Dr. Collins answers questions about how NIH is addressing the opioid epidemic </span> <span class="field field--name-uid field--type-entity-reference field--label-hidden"><span>Anonymous</span></span> <span class="field field--name-created field--type-created field--label-hidden"><time datetime="2025-03-03T10:42:18-05:00" title="Monday, March 3, 2025 - 10:42" class="datetime">Mon, 03/03/2025 - 10:42</time> </span> <div class="field field--name-field-link-description field--type-string-long field--label-hidden field__item">Dr. Collins answers questions about what NIH is doing to address the opioid crisis. He talks about factors that led to the over-prescription of opioids, how pain and pain management is being considered, and NIH research looking at alternatives to opioids, solutions to and prevention methods for addiction. WebMD. March 14, 2018. </div> <div class="field field--name-field-item-link field--type-link field--label-hidden field__item"><a href="https://www.webmd.com/special-reports/opioids-pain/20180314/opioid-collins">In a Q&A with WebMD, Dr. Collins answers questions about how NIH is addressing …</a></div> <div class="field field--name-field-site-section field--type-entity-reference field--label-hidden field__item"><a href="/taxonomy/term/536" hreflang="en">The NIH Director</a></div> <div class="field field--name-field-organization field--type-entity-reference field--label-hidden field__item"><a href="/taxonomy/term/6" hreflang="en">OD</a></div> <div class="field field--name-field-publish-date field--type-datetime field--label-hidden field__item"><time datetime="2018-03-14T12:00:00Z" class="datetime">Wed, 03/14/2018 - 12:00</time> </div> Mon, 03 Mar 2025 15:42:18 +0000 Anonymous 14886 at /node/14881 <span class="field field--name-title field--type-string field--label-hidden">Dr. Collins co-authors a paper in Neuron giving recommendations for advancing research on music's effects on the brain </span> <span class="field field--name-uid field--type-entity-reference field--label-hidden"><span>Anonymous</span></span> <span class="field field--name-created field--type-created field--label-hidden"><time datetime="2025-03-03T10:42:18-05:00" title="Monday, March 3, 2025 - 10:42" class="datetime">Mon, 03/03/2025 - 10:42</time> </span> <div class="field field--name-field-link-description field--type-string-long field--label-hidden field__item">In a paper published by Neuron, a panel of experts from the June 2017 Sound Health Workshop shared research recommendations to accelerate the study of music's effects on the brain. Neuron. Online: March 23, 2018.</div> <div class="field field--name-field-item-link field--type-link field--label-hidden field__item"><a href="http://www.cell.com/neuron/fulltext/S0896-6273(18)30103-X">Dr. Collins co-authors a paper in Neuron giving recommendations for advancing r…</a></div> <div class="field field--name-field-site-section field--type-entity-reference field--label-hidden field__item"><a href="/taxonomy/term/536" hreflang="en">The NIH Director</a></div> <div class="field field--name-field-organization field--type-entity-reference field--label-hidden field__item"><a href="/taxonomy/term/6" hreflang="en">OD</a></div> <div class="field field--name-field-publish-date field--type-datetime field--label-hidden field__item"><time datetime="2018-03-23T12:00:00Z" class="datetime">Fri, 03/23/2018 - 12:00</time> </div> Mon, 03 Mar 2025 15:42:18 +0000 Anonymous 14881 at /node/14876 <span class="field field--name-title field--type-string field--label-hidden">Dr. Collins is featured in Retro Report’s “Finding the Code,” the first in a series on precision medicine</span> <span class="field field--name-uid field--type-entity-reference field--label-hidden"><span>Anonymous</span></span> <span class="field field--name-created field--type-created field--label-hidden"><time datetime="2025-03-03T10:42:16-05:00" title="Monday, March 3, 2025 - 10:42" class="datetime">Mon, 03/03/2025 - 10:42</time> </span> <div class="field field--name-field-link-description field--type-string-long field--label-hidden field__item">Retro Report in partnership with STAT produced a three-part series called "The Code." Dr. Collins is featured in the first episode "Finding the Code" about the Human Genome Project and the race to sequence the human genome.</div> <div class="field field--name-field-item-link field--type-link field--label-hidden field__item"><a href="https://www.retroreport.org/video/finding-the-code--the-race-to-sequence-the-human-genome-and-what-it-means/">Dr. Collins is featured in Retro Report’s “Finding the Code,” the first in a se…</a></div> <div class="field field--name-field-site-section field--type-entity-reference field--label-hidden field__item"><a href="/taxonomy/term/536" hreflang="en">The NIH Director</a></div> <div class="field field--name-field-organization field--type-entity-reference field--label-hidden field__item"><a href="/taxonomy/term/6" hreflang="en">OD</a></div> <div class="field field--name-field-publish-date field--type-datetime field--label-hidden field__item"><time datetime="2018-04-02T12:00:00Z" class="datetime">Mon, 04/02/2018 - 12:00</time> </div> Mon, 03 Mar 2025 15:42:16 +0000 Anonymous 14876 at